Ion channels as therapeutic antibody targets

It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to...

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Detalles Bibliográficos
Autores principales: Hutchings, Catherine J., Colussi, Paul, Clark, Theodore G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380435/
https://www.ncbi.nlm.nih.gov/pubmed/30526315
http://dx.doi.org/10.1080/19420862.2018.1548232
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author Hutchings, Catherine J.
Colussi, Paul
Clark, Theodore G.
author_facet Hutchings, Catherine J.
Colussi, Paul
Clark, Theodore G.
author_sort Hutchings, Catherine J.
collection PubMed
description It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target ion channels have been reported. Antibodies currently in development and progressing towards the clinic are highlighted.
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spelling pubmed-63804352019-02-26 Ion channels as therapeutic antibody targets Hutchings, Catherine J. Colussi, Paul Clark, Theodore G. MAbs Review It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target ion channels have been reported. Antibodies currently in development and progressing towards the clinic are highlighted. Taylor & Francis 2018-12-10 /pmc/articles/PMC6380435/ /pubmed/30526315 http://dx.doi.org/10.1080/19420862.2018.1548232 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Hutchings, Catherine J.
Colussi, Paul
Clark, Theodore G.
Ion channels as therapeutic antibody targets
title Ion channels as therapeutic antibody targets
title_full Ion channels as therapeutic antibody targets
title_fullStr Ion channels as therapeutic antibody targets
title_full_unstemmed Ion channels as therapeutic antibody targets
title_short Ion channels as therapeutic antibody targets
title_sort ion channels as therapeutic antibody targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380435/
https://www.ncbi.nlm.nih.gov/pubmed/30526315
http://dx.doi.org/10.1080/19420862.2018.1548232
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