Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens’ optimization led to prompt resolution of symptoms in one. Patients on second-line ataz...

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Autores principales: Ssebambulidde, Kenneth, Segawa, Ivan, Laker, Eva, Lamorde, Mohammed, Castelnouvo, Barbara, Nakasujja, Noeline, Calcagno, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380528/
https://www.ncbi.nlm.nih.gov/pubmed/30800328
http://dx.doi.org/10.1093/omcr/omy132
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author Ssebambulidde, Kenneth
Segawa, Ivan
Laker, Eva
Lamorde, Mohammed
Castelnouvo, Barbara
Nakasujja, Noeline
Calcagno, Andrea
author_facet Ssebambulidde, Kenneth
Segawa, Ivan
Laker, Eva
Lamorde, Mohammed
Castelnouvo, Barbara
Nakasujja, Noeline
Calcagno, Andrea
author_sort Ssebambulidde, Kenneth
collection PubMed
description Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens’ optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.
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spelling pubmed-63805282019-02-22 Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda Ssebambulidde, Kenneth Segawa, Ivan Laker, Eva Lamorde, Mohammed Castelnouvo, Barbara Nakasujja, Noeline Calcagno, Andrea Oxf Med Case Reports Case Report Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens’ optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape. Oxford University Press 2019-02-16 /pmc/articles/PMC6380528/ /pubmed/30800328 http://dx.doi.org/10.1093/omcr/omy132 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Ssebambulidde, Kenneth
Segawa, Ivan
Laker, Eva
Lamorde, Mohammed
Castelnouvo, Barbara
Nakasujja, Noeline
Calcagno, Andrea
Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title_full Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title_fullStr Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title_full_unstemmed Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title_short Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda
title_sort symptomatic cerebrospinal fluid hiv-1 escape in two patients on second-line antiretroviral therapy in uganda
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380528/
https://www.ncbi.nlm.nih.gov/pubmed/30800328
http://dx.doi.org/10.1093/omcr/omy132
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