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Gender based survival prediction models for heart failure patients: A case study in Pakistan

OBJECTIVES: The objective of this study was to build and assess the performance of survival prediction models using the gender-specific informative risk factors for patients with left ventricular systolic dysfunction. METHODS: A lasso approach was used to decide the informative predictors for buildi...

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Autores principales: Zahid, Faisal Maqbool, Ramzan, Shakeela, Faisal, Shahla, Hussain, Ijaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380566/
https://www.ncbi.nlm.nih.gov/pubmed/30779736
http://dx.doi.org/10.1371/journal.pone.0210602
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author Zahid, Faisal Maqbool
Ramzan, Shakeela
Faisal, Shahla
Hussain, Ijaz
author_facet Zahid, Faisal Maqbool
Ramzan, Shakeela
Faisal, Shahla
Hussain, Ijaz
author_sort Zahid, Faisal Maqbool
collection PubMed
description OBJECTIVES: The objective of this study was to build and assess the performance of survival prediction models using the gender-specific informative risk factors for patients with left ventricular systolic dysfunction. METHODS: A lasso approach was used to decide the informative predictors for building semi-parametric proportional hazards Cox model. Separate models were built for all patients [N = 299], male patients [N(male) = 194 (64.88%)], and female patients [N(female) = 105 (35.12%)], to observe the risk factors associated with the individual’s risk of death. The likelihood- ratio test was used to test the goodness of fit of the selected model, and the C-index was used to assess the predictive performance of the selected model(s) with respect to the overall model with all observed risk factors. RESULTS: The survival prediction model for females is notably different from that for males. For males, smoking, diabetes, and anaemia, whereas for females, ejection fraction, sodium, and platelets count are non-informative with zero regression coefficients. The goodness of fit of the selected models with respect to the general model with all observed risk factors is tested using the likelihood-ratio test. The results are in favor of the selected models with p-values 0.51,0.61, and 0.70 for all patients, male patients, and female patients, respectively. The same values of C-index for the full model and the selected models for overall data, for males, and for females (0.72, 0.73, and 0.77 for overall data, male data, and female data, respectively) indicate that the selected models are as good as the corresponding overall models regarding their predictive performance. CONCLUSION: There is a substantial difference in the survival prediction models for heart failure (HF) of male and female patients in this study. More studies are needed in Pakistan for confirming this striking male-female difference regarding the potential risk factors to predict survival with heart failure.
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spelling pubmed-63805662019-03-01 Gender based survival prediction models for heart failure patients: A case study in Pakistan Zahid, Faisal Maqbool Ramzan, Shakeela Faisal, Shahla Hussain, Ijaz PLoS One Research Article OBJECTIVES: The objective of this study was to build and assess the performance of survival prediction models using the gender-specific informative risk factors for patients with left ventricular systolic dysfunction. METHODS: A lasso approach was used to decide the informative predictors for building semi-parametric proportional hazards Cox model. Separate models were built for all patients [N = 299], male patients [N(male) = 194 (64.88%)], and female patients [N(female) = 105 (35.12%)], to observe the risk factors associated with the individual’s risk of death. The likelihood- ratio test was used to test the goodness of fit of the selected model, and the C-index was used to assess the predictive performance of the selected model(s) with respect to the overall model with all observed risk factors. RESULTS: The survival prediction model for females is notably different from that for males. For males, smoking, diabetes, and anaemia, whereas for females, ejection fraction, sodium, and platelets count are non-informative with zero regression coefficients. The goodness of fit of the selected models with respect to the general model with all observed risk factors is tested using the likelihood-ratio test. The results are in favor of the selected models with p-values 0.51,0.61, and 0.70 for all patients, male patients, and female patients, respectively. The same values of C-index for the full model and the selected models for overall data, for males, and for females (0.72, 0.73, and 0.77 for overall data, male data, and female data, respectively) indicate that the selected models are as good as the corresponding overall models regarding their predictive performance. CONCLUSION: There is a substantial difference in the survival prediction models for heart failure (HF) of male and female patients in this study. More studies are needed in Pakistan for confirming this striking male-female difference regarding the potential risk factors to predict survival with heart failure. Public Library of Science 2019-02-19 /pmc/articles/PMC6380566/ /pubmed/30779736 http://dx.doi.org/10.1371/journal.pone.0210602 Text en © 2019 Zahid et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zahid, Faisal Maqbool
Ramzan, Shakeela
Faisal, Shahla
Hussain, Ijaz
Gender based survival prediction models for heart failure patients: A case study in Pakistan
title Gender based survival prediction models for heart failure patients: A case study in Pakistan
title_full Gender based survival prediction models for heart failure patients: A case study in Pakistan
title_fullStr Gender based survival prediction models for heart failure patients: A case study in Pakistan
title_full_unstemmed Gender based survival prediction models for heart failure patients: A case study in Pakistan
title_short Gender based survival prediction models for heart failure patients: A case study in Pakistan
title_sort gender based survival prediction models for heart failure patients: a case study in pakistan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380566/
https://www.ncbi.nlm.nih.gov/pubmed/30779736
http://dx.doi.org/10.1371/journal.pone.0210602
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