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IL-11 prevents IFN-γ-induced hepatocyte death through selective downregulation of IFN-γ/STAT1 signaling and ROS scavenging

AIMS: Interferon-γ (IFN-γ) exhibits hepatotoxicity through signal transducer and activator of transcription 1 (STAT1) activation. On the contrary, interleukin-11 (IL-11) shows tissue-protective effects on various organs including the liver through STAT3 activation. Here, we found that IL-11 pretreat...

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Detalles Bibliográficos
Autores principales:	Miyawaki, Akimitsu, Iizuka, Yoshiko, Sugino, Hitomi, Watanabe, Yoshifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380568/ https://www.ncbi.nlm.nih.gov/pubmed/30779746 http://dx.doi.org/10.1371/journal.pone.0211123

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