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Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380677/ https://www.ncbi.nlm.nih.gov/pubmed/30702565 http://dx.doi.org/10.1097/MD.0000000000014107 |
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author | Wang, Pei-pei Zhou, Xi Chen, Xi Wang, Li-wen Liu, Yong |
author_facet | Wang, Pei-pei Zhou, Xi Chen, Xi Wang, Li-wen Liu, Yong |
author_sort | Wang, Pei-pei |
collection | PubMed |
description | RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant melanoma with spinal metastasis. INTERVENTIONS AND OUTCOMES: The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation. The patient's hypercalcemia was controlled and muscle strength was partially recovered. The immunohistochemical stainings showed Melan-A (+), HMB45 (+), s-100 (+), Vimentin (+), and AE1/AE3 (−). LESSONS: We emphasize the necessity of screening potential existence of neoplasms for the patients with hypercalcemia. Surgical treatment is still necessary for patients with spinal metastasis. |
format | Online Article Text |
id | pubmed-6380677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63806772019-03-04 Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report Wang, Pei-pei Zhou, Xi Chen, Xi Wang, Li-wen Liu, Yong Medicine (Baltimore) Research Article RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant melanoma with spinal metastasis. INTERVENTIONS AND OUTCOMES: The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation. The patient's hypercalcemia was controlled and muscle strength was partially recovered. The immunohistochemical stainings showed Melan-A (+), HMB45 (+), s-100 (+), Vimentin (+), and AE1/AE3 (−). LESSONS: We emphasize the necessity of screening potential existence of neoplasms for the patients with hypercalcemia. Surgical treatment is still necessary for patients with spinal metastasis. Wolters Kluwer Health 2019-02-01 /pmc/articles/PMC6380677/ /pubmed/30702565 http://dx.doi.org/10.1097/MD.0000000000014107 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Wang, Pei-pei Zhou, Xi Chen, Xi Wang, Li-wen Liu, Yong Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title | Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title_full | Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title_fullStr | Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title_full_unstemmed | Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title_short | Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report |
title_sort | malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: a case report |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380677/ https://www.ncbi.nlm.nih.gov/pubmed/30702565 http://dx.doi.org/10.1097/MD.0000000000014107 |
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