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Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report

RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant me...

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Autores principales: Wang, Pei-pei, Zhou, Xi, Chen, Xi, Wang, Li-wen, Liu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380677/
https://www.ncbi.nlm.nih.gov/pubmed/30702565
http://dx.doi.org/10.1097/MD.0000000000014107
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author Wang, Pei-pei
Zhou, Xi
Chen, Xi
Wang, Li-wen
Liu, Yong
author_facet Wang, Pei-pei
Zhou, Xi
Chen, Xi
Wang, Li-wen
Liu, Yong
author_sort Wang, Pei-pei
collection PubMed
description RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant melanoma with spinal metastasis. INTERVENTIONS AND OUTCOMES: The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation. The patient's hypercalcemia was controlled and muscle strength was partially recovered. The immunohistochemical stainings showed Melan-A (+), HMB45 (+), s-100 (+), Vimentin (+), and AE1/AE3 (−). LESSONS: We emphasize the necessity of screening potential existence of neoplasms for the patients with hypercalcemia. Surgical treatment is still necessary for patients with spinal metastasis.
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spelling pubmed-63806772019-03-04 Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report Wang, Pei-pei Zhou, Xi Chen, Xi Wang, Li-wen Liu, Yong Medicine (Baltimore) Research Article RATIONALE: Malignant melanoma with indiscoverable skin manifestations is unusual and refractory hypercalcemia with high metabolic signal of the rectum as initial manifestation is very rare. PATIENT CONCERNS: We present a case that presented with paresis, nausea, and vomiting. DIAGNOSES: Malignant melanoma with spinal metastasis. INTERVENTIONS AND OUTCOMES: The patient underwent posterior decompression, partial tumor resection, bone cement reconstruction, and internal fixation. The patient's hypercalcemia was controlled and muscle strength was partially recovered. The immunohistochemical stainings showed Melan-A (+), HMB45 (+), s-100 (+), Vimentin (+), and AE1/AE3 (−). LESSONS: We emphasize the necessity of screening potential existence of neoplasms for the patients with hypercalcemia. Surgical treatment is still necessary for patients with spinal metastasis. Wolters Kluwer Health 2019-02-01 /pmc/articles/PMC6380677/ /pubmed/30702565 http://dx.doi.org/10.1097/MD.0000000000014107 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Wang, Pei-pei
Zhou, Xi
Chen, Xi
Wang, Li-wen
Liu, Yong
Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title_full Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title_fullStr Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title_full_unstemmed Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title_short Malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: A case report
title_sort malignant melanoma with indiscoverable skin manifestations presenting with paresis and refractory hypercalcemia: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380677/
https://www.ncbi.nlm.nih.gov/pubmed/30702565
http://dx.doi.org/10.1097/MD.0000000000014107
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