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Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma

To explore the role of hScrib in the pathogenesis of endometriosis. This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared...

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Autores principales: Ouyang, Zhuo, Chen, Minxiu, Sun, Jinping, Zhai, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380690/
https://www.ncbi.nlm.nih.gov/pubmed/30702562
http://dx.doi.org/10.1097/MD.0000000000014076
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author Ouyang, Zhuo
Chen, Minxiu
Sun, Jinping
Zhai, Jianjun
author_facet Ouyang, Zhuo
Chen, Minxiu
Sun, Jinping
Zhai, Jianjun
author_sort Ouyang, Zhuo
collection PubMed
description To explore the role of hScrib in the pathogenesis of endometriosis. This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared the differences among them. Serum levels, protein expressions, localizations, and correlations of hScrib and E-cadherin were determined. The levels of serum soluble hScrib and E-cadherin were significantly highest in EC, followed by EMs, and healthy women (P < .05). hScrib protein content was opposite result in 3 tissues (P < .05), and was negatively correlated with r-AFS stage in EMs. The location changed from membrane to cytoplasm. Co-localization of hScrib with E-cadherin was found at extensive cell–cell boundaries in EMs. hScrib and E-cadherin may be as new diagnostic markers of endometriosis. Low expression of hScrib leads to the loss of cell polarity and stability. Also, hScrib may induce EMT through regulating E-cadherin, might play an important role in pathogenesis of endometriosis.
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spelling pubmed-63806902019-03-04 Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma Ouyang, Zhuo Chen, Minxiu Sun, Jinping Zhai, Jianjun Medicine (Baltimore) Research Article To explore the role of hScrib in the pathogenesis of endometriosis. This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared the differences among them. Serum levels, protein expressions, localizations, and correlations of hScrib and E-cadherin were determined. The levels of serum soluble hScrib and E-cadherin were significantly highest in EC, followed by EMs, and healthy women (P < .05). hScrib protein content was opposite result in 3 tissues (P < .05), and was negatively correlated with r-AFS stage in EMs. The location changed from membrane to cytoplasm. Co-localization of hScrib with E-cadherin was found at extensive cell–cell boundaries in EMs. hScrib and E-cadherin may be as new diagnostic markers of endometriosis. Low expression of hScrib leads to the loss of cell polarity and stability. Also, hScrib may induce EMT through regulating E-cadherin, might play an important role in pathogenesis of endometriosis. Wolters Kluwer Health 2019-02-01 /pmc/articles/PMC6380690/ /pubmed/30702562 http://dx.doi.org/10.1097/MD.0000000000014076 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Ouyang, Zhuo
Chen, Minxiu
Sun, Jinping
Zhai, Jianjun
Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title_full Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title_fullStr Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title_full_unstemmed Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title_short Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
title_sort expression and role of hscrib in endometrium, endometriosis, and endometrial adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380690/
https://www.ncbi.nlm.nih.gov/pubmed/30702562
http://dx.doi.org/10.1097/MD.0000000000014076
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