Exposure to Sub-inhibitory Concentrations of the Chemosensitizer 1-(1-Naphthylmethyl)-Piperazine Creates Membrane Destabilization in Multi-Drug Resistant Klebsiella pneumoniae

Antimicrobial efflux is one of the important mechanisms causing multi-drug resistance (MDR) in bacteria. Chemosensitizers like 1-(1-naphthylmethyl)-piperazine (NMP) can inhibit an efflux pump and therefore can overcome MDR. However, secondary effects of NMP other than efflux pump inhibition are rare...

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Detalles Bibliográficos
Autores principales: Anes, João, Sivasankaran, Sathesh K., Muthappa, Dechamma M., Fanning, Séamus, Srikumar, Shabarinath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381021/
https://www.ncbi.nlm.nih.gov/pubmed/30814979
http://dx.doi.org/10.3389/fmicb.2019.00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381021/
https://www.ncbi.nlm.nih.gov/pubmed/30814979
http://dx.doi.org/10.3389/fmicb.2019.00092

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