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Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains

Vaccines that confer protection through induction of adaptive T-cell immunity rely on understanding T-cell epitope (TCE) evolution induced by immune escape. This is poorly understood in tuberculosis (TB), an ancient, chronic disease, where CD4 T-cell immunity is of recognized importance. We probed 9...

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Detalles Bibliográficos
Autores principales:	Ramaiah, Arunachalam, Nayak, Soumya, Rakshit, Srabanti, Manson, Abigail L., Abeel, Thomas, Shanmugam, Sivakumar, Sahoo, Pravat Nalini, John, Anto Jesuraj Uday Kumar, Sundaramurthi, Jagadish Chandrabose, Narayanan, Sujatha, D'Souza, George, von Hoegen, Paul, Ottenhoff, Tom H. M., Swaminathan, Soumya, Earl, Ashlee M., Vyakarnam, Annapurna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381025/ https://www.ncbi.nlm.nih.gov/pubmed/30814998 http://dx.doi.org/10.3389/fimmu.2019.00195

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