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A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level

In natural environments our auditory system is exposed to multiple and diverse signals of fluctuating amplitudes. Therefore, to detect, localize, and single out individual sounds the auditory system has to process and filter spectral and temporal information from both ears. It is known that the over...

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Autores principales: Siveke, Ida, Lingner, Andrea, Ammer, Julian J., Gleiss, Sarah A., Grothe, Benedikt, Felmy, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381077/
https://www.ncbi.nlm.nih.gov/pubmed/30814933
http://dx.doi.org/10.3389/fncir.2019.00008
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author Siveke, Ida
Lingner, Andrea
Ammer, Julian J.
Gleiss, Sarah A.
Grothe, Benedikt
Felmy, Felix
author_facet Siveke, Ida
Lingner, Andrea
Ammer, Julian J.
Gleiss, Sarah A.
Grothe, Benedikt
Felmy, Felix
author_sort Siveke, Ida
collection PubMed
description In natural environments our auditory system is exposed to multiple and diverse signals of fluctuating amplitudes. Therefore, to detect, localize, and single out individual sounds the auditory system has to process and filter spectral and temporal information from both ears. It is known that the overall sound pressure level affects sensory signal transduction and therefore the temporal response pattern of auditory neurons. We hypothesize that the mammalian binaural system utilizes a dynamic mechanism to adjust the temporal filters in neuronal circuits to different overall sound pressure levels. Previous studies proposed an inhibitory mechanism generated by the reciprocally coupled dorsal nuclei of the lateral lemniscus (DNLL) as a temporal neuronal-network filter that suppresses rapid binaural fluctuations. Here we investigated the consequence of different sound levels on this filter during binaural processing. Our in vivo and in vitro electrophysiology in Mongolian gerbils shows that the integration of ascending excitation and contralateral inhibition defines the temporal properties of this inhibitory filter. The time course of this filter depends on the synaptic drive, which is modulated by the overall sound pressure level and N-methyl-D-aspartate receptor (NMDAR) signaling. In psychophysical experiments we tested the temporal perception of humans and show that detection and localization of two subsequent tones changes with the sound pressure level consistent with our physiological results. Together our data support the hypothesis that mammals dynamically adjust their time window for sound detection and localization within the binaural system in a sound level dependent manner.
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spelling pubmed-63810772019-02-27 A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level Siveke, Ida Lingner, Andrea Ammer, Julian J. Gleiss, Sarah A. Grothe, Benedikt Felmy, Felix Front Neural Circuits Neuroscience In natural environments our auditory system is exposed to multiple and diverse signals of fluctuating amplitudes. Therefore, to detect, localize, and single out individual sounds the auditory system has to process and filter spectral and temporal information from both ears. It is known that the overall sound pressure level affects sensory signal transduction and therefore the temporal response pattern of auditory neurons. We hypothesize that the mammalian binaural system utilizes a dynamic mechanism to adjust the temporal filters in neuronal circuits to different overall sound pressure levels. Previous studies proposed an inhibitory mechanism generated by the reciprocally coupled dorsal nuclei of the lateral lemniscus (DNLL) as a temporal neuronal-network filter that suppresses rapid binaural fluctuations. Here we investigated the consequence of different sound levels on this filter during binaural processing. Our in vivo and in vitro electrophysiology in Mongolian gerbils shows that the integration of ascending excitation and contralateral inhibition defines the temporal properties of this inhibitory filter. The time course of this filter depends on the synaptic drive, which is modulated by the overall sound pressure level and N-methyl-D-aspartate receptor (NMDAR) signaling. In psychophysical experiments we tested the temporal perception of humans and show that detection and localization of two subsequent tones changes with the sound pressure level consistent with our physiological results. Together our data support the hypothesis that mammals dynamically adjust their time window for sound detection and localization within the binaural system in a sound level dependent manner. Frontiers Media S.A. 2019-02-13 /pmc/articles/PMC6381077/ /pubmed/30814933 http://dx.doi.org/10.3389/fncir.2019.00008 Text en Copyright © Siveke, Lingner, Ammer, Gleiss, Grothe and Felmy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Siveke, Ida
Lingner, Andrea
Ammer, Julian J.
Gleiss, Sarah A.
Grothe, Benedikt
Felmy, Felix
A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title_full A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title_fullStr A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title_full_unstemmed A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title_short A Temporal Filter for Binaural Hearing Is Dynamically Adjusted by Sound Pressure Level
title_sort temporal filter for binaural hearing is dynamically adjusted by sound pressure level
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381077/
https://www.ncbi.nlm.nih.gov/pubmed/30814933
http://dx.doi.org/10.3389/fncir.2019.00008
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