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CD8(+) T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Narcolepsy Type 1 (NT1) is a neurological sleep disorder, characterized by the loss of hypocretin/orexin signaling in the brain. Genetic, epidemiological and experimental data support the hypothesis that NT1 is a T-cell-mediated autoimmune disease targeting the hypocretin producing neurons. While au...

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Detalles Bibliográficos
Autores principales:	Pedersen, Natasja Wulff, Holm, Anja, Kristensen, Nikolaj Pagh, Bjerregaard, Anne-Mette, Bentzen, Amalie Kai, Marquard, Andrea Marion, Tamhane, Tripti, Burgdorf, Kristoffer Sølvsten, Ullum, Henrik, Jennum, Poul, Knudsen, Stine, Hadrup, Sine Reker, Kornum, Birgitte Rahbek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381094/ https://www.ncbi.nlm.nih.gov/pubmed/30783092 http://dx.doi.org/10.1038/s41467-019-08774-1

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