A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1–FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial‐specific...

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Detalles Bibliográficos
Autores principales: Kim, Yoo Hyung, Choi, Jeongwoon, Yang, Myung Jin, Hong, Seon Pyo, Lee, Choong-kun, Kubota, Yoshiaki, Lim, Dae-Sik, Koh, Gou Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381131/
https://www.ncbi.nlm.nih.gov/pubmed/30783090
http://dx.doi.org/10.1038/s41467-019-08773-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381131/
https://www.ncbi.nlm.nih.gov/pubmed/30783090
http://dx.doi.org/10.1038/s41467-019-08773-2

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