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Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients

CD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinflammation in relapsing-remitting multiple sclerosis (RR-MS), to date,...

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Autores principales: Álvarez-Sánchez, Nuria, Cruz-Chamorro, Ivan, Díaz-Sánchez, María, Lardone, Patricia Judith, Guerrero, Juan Miguel, Carrillo-Vico, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381140/
https://www.ncbi.nlm.nih.gov/pubmed/30783191
http://dx.doi.org/10.1038/s41598-019-38897-w
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author Álvarez-Sánchez, Nuria
Cruz-Chamorro, Ivan
Díaz-Sánchez, María
Lardone, Patricia Judith
Guerrero, Juan Miguel
Carrillo-Vico, Antonio
author_facet Álvarez-Sánchez, Nuria
Cruz-Chamorro, Ivan
Díaz-Sánchez, María
Lardone, Patricia Judith
Guerrero, Juan Miguel
Carrillo-Vico, Antonio
author_sort Álvarez-Sánchez, Nuria
collection PubMed
description CD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinflammation in relapsing-remitting multiple sclerosis (RR-MS), to date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus, our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and expression of CD39 and the CD39(+) Treg frequency were measured in PBMCs from 55 relapsing RR-MS patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired controls. Moreover, the association between CD39(+) Tregs and RR-MS was assessed by multivariate logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing RR-MS patients. Moreover, CD39(+) Tregs were significantly correlated with the EDSS score and were independently associated with the odds of RR-MS. Our results highlight the relevance of CD39(+) Treg subset in the clinical outcomes of RR-MS.
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spelling pubmed-63811402019-02-22 Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients Álvarez-Sánchez, Nuria Cruz-Chamorro, Ivan Díaz-Sánchez, María Lardone, Patricia Judith Guerrero, Juan Miguel Carrillo-Vico, Antonio Sci Rep Article CD39, an ectonucleotidase that hydrolyses pro-inflammatory ATP, is a marker of highly active and suppressive T regulatory cells (Tregs). Although CD39 has a role in Treg suppression and might be important in the control of neuroinflammation in relapsing-remitting multiple sclerosis (RR-MS), to date, there are contradictory reports concerning the Tregs expression of CD39 in RR-MS patients. Thus, our objectives were to assess the activity and expression of CD39, especially in Tregs from peripheral blood mononuclear cells (PBMCs) of relapsing RR-MS patients compared with control subjects and to evaluate the association of CD39+ Tregs with disability and the odds of RR-MS. The activity and expression of CD39 and the CD39(+) Treg frequency were measured in PBMCs from 55 relapsing RR-MS patients (19 untreated and 36 receiving immunomodulatory treatment) and 55 age- and sex-paired controls. Moreover, the association between CD39(+) Tregs and RR-MS was assessed by multivariate logistic regression. CD39 activity and the frequency of CD39-expressing Tregs were elevated in relapsing RR-MS patients. Moreover, CD39(+) Tregs were significantly correlated with the EDSS score and were independently associated with the odds of RR-MS. Our results highlight the relevance of CD39(+) Treg subset in the clinical outcomes of RR-MS. Nature Publishing Group UK 2019-02-19 /pmc/articles/PMC6381140/ /pubmed/30783191 http://dx.doi.org/10.1038/s41598-019-38897-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Álvarez-Sánchez, Nuria
Cruz-Chamorro, Ivan
Díaz-Sánchez, María
Lardone, Patricia Judith
Guerrero, Juan Miguel
Carrillo-Vico, Antonio
Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title_full Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title_fullStr Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title_full_unstemmed Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title_short Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
title_sort peripheral cd39-expressing t regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381140/
https://www.ncbi.nlm.nih.gov/pubmed/30783191
http://dx.doi.org/10.1038/s41598-019-38897-w
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