Suppression of autophagic activity by Rubicon is a signature of aging

Autophagy, an evolutionarily conserved cytoplasmic degradation system, has been implicated as a convergent mechanism in various longevity pathways. Autophagic activity decreases with age in several organisms, but the underlying mechanism is unclear. Here, we show that the expression of Rubicon, a ne...

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Detalles Bibliográficos
Autores principales: Nakamura, Shuhei, Oba, Masaki, Suzuki, Mari, Takahashi, Atsushi, Yamamuro, Tadashi, Fujiwara, Mari, Ikenaka, Kensuke, Minami, Satoshi, Tabata, Namine, Yamamoto, Kenichi, Kubo, Sayaka, Tokumura, Ayaka, Akamatsu, Kanako, Miyazaki, Yumi, Kawabata, Tsuyoshi, Hamasaki, Maho, Fukui, Koji, Sango, Kazunori, Watanabe, Yoshihisa, Takabatake, Yoshitsugu, Kitajima, Tomoya S., Okada, Yukinori, Mochizuki, Hideki, Isaka, Yoshitaka, Antebi, Adam, Yoshimori, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381146/
https://www.ncbi.nlm.nih.gov/pubmed/30783089
http://dx.doi.org/10.1038/s41467-019-08729-6

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