Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains...

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Detalles Bibliográficos
Autores principales: Lin, Chuangxin, Liu, Liangliang, Zeng, Chun, Cui, Zhong-Kai, Chen, Yuhui, Lai, Pinling, Wang, Hong, Shao, Yan, Zhang, Haiyan, Zhang, Rongkai, Zhao, Chang, Fang, Hang, Cai, Daozhang, Bai, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381187/
https://www.ncbi.nlm.nih.gov/pubmed/30792936
http://dx.doi.org/10.1038/s41413-018-0041-8

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