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Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok (−/−) zebrafish
Deoxyguanosine kinase (dGK) is an essential rate-limiting component of the mitochondrial purine nucleotide salvage pathway, encoded by the nuclear gene encoding deoxyguanosine kinase (DGUOK). Mutations in DGUOK lead to mitochondrial DNA (mtDNA) depletion typically in the liver and brain, causing a h...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381312/ https://www.ncbi.nlm.nih.gov/pubmed/30428046 http://dx.doi.org/10.1093/hmg/ddy389 |