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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis. METHODS: We obtained mucosal biopsies (N = 236) collected from terminal ile...

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Detalles Bibliográficos
Autores principales:	Howell, Kate Joanne, Kraiczy, Judith, Nayak, Komal M., Gasparetto, Marco, Ross, Alexander, Lee, Claire, Mak, Tim N., Koo, Bon-Kyoung, Kumar, Nitin, Lawley, Trevor, Sinha, Anupam, Rosenstiel, Philip, Heuschkel, Robert, Stegle, Oliver, Zilbauer, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	W.B. Saunders 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381389/ https://www.ncbi.nlm.nih.gov/pubmed/29031501 http://dx.doi.org/10.1053/j.gastro.2017.10.007

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