Down-Regulation of miRNA-708 Promotes Aberrant Calcium Signaling by Targeting Neuronatin in a Mouse Model of Angelman Syndrome

The expression of ubiquitin ligase UBE3A is paternally imprinted in neurons and loss of function of maternally inherited UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder characterized by severe intellectual disability and motor disturbances. Over activation of UBE3A is also linked...

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Detalles Bibliográficos
Autores principales: Vatsa, Naman, Kumar, Vipendra, Singh, Brijesh Kumar, Kumar, Shashi Shekhar, Sharma, Ankit, Jana, Nihar Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381399/
https://www.ncbi.nlm.nih.gov/pubmed/30814928
http://dx.doi.org/10.3389/fnmol.2019.00035

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