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An update on oxysterol biochemistry: New discoveries in lipidomics

Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxystero...

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Detalles Bibliográficos
Autores principales: Griffiths, William J., Wang, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381446/
https://www.ncbi.nlm.nih.gov/pubmed/29421651
http://dx.doi.org/10.1016/j.bbrc.2018.02.019
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author Griffiths, William J.
Wang, Yuqin
author_facet Griffiths, William J.
Wang, Yuqin
author_sort Griffiths, William J.
collection PubMed
description Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries.
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spelling pubmed-63814462019-02-28 An update on oxysterol biochemistry: New discoveries in lipidomics Griffiths, William J. Wang, Yuqin Biochem Biophys Res Commun Article Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries. Elsevier 2018-10-07 /pmc/articles/PMC6381446/ /pubmed/29421651 http://dx.doi.org/10.1016/j.bbrc.2018.02.019 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Griffiths, William J.
Wang, Yuqin
An update on oxysterol biochemistry: New discoveries in lipidomics
title An update on oxysterol biochemistry: New discoveries in lipidomics
title_full An update on oxysterol biochemistry: New discoveries in lipidomics
title_fullStr An update on oxysterol biochemistry: New discoveries in lipidomics
title_full_unstemmed An update on oxysterol biochemistry: New discoveries in lipidomics
title_short An update on oxysterol biochemistry: New discoveries in lipidomics
title_sort update on oxysterol biochemistry: new discoveries in lipidomics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381446/
https://www.ncbi.nlm.nih.gov/pubmed/29421651
http://dx.doi.org/10.1016/j.bbrc.2018.02.019
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