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An update on oxysterol biochemistry: New discoveries in lipidomics
Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxystero...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381446/ https://www.ncbi.nlm.nih.gov/pubmed/29421651 http://dx.doi.org/10.1016/j.bbrc.2018.02.019 |
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author | Griffiths, William J. Wang, Yuqin |
author_facet | Griffiths, William J. Wang, Yuqin |
author_sort | Griffiths, William J. |
collection | PubMed |
description | Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries. |
format | Online Article Text |
id | pubmed-6381446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63814462019-02-28 An update on oxysterol biochemistry: New discoveries in lipidomics Griffiths, William J. Wang, Yuqin Biochem Biophys Res Commun Article Oxysterols are oxidised derivatives of cholesterol or its precursors post lanosterol. They are intermediates in the biosynthesis of bile acids, steroid hormones and 1,25-dihydroxyvitamin D(3.) Although often considered as metabolic intermediates there is a growing body of evidence that many oxysterols are bioactive and their absence or excess may be part of the cause of a disease phenotype. Using global lipidomics approaches oxysterols are underrepresented encouraging the development of targeted approaches. In this article, we discuss recent discoveries important in oxysterol biochemistry and some of the targeted lipidomic approaches used to make these discoveries. Elsevier 2018-10-07 /pmc/articles/PMC6381446/ /pubmed/29421651 http://dx.doi.org/10.1016/j.bbrc.2018.02.019 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Griffiths, William J. Wang, Yuqin An update on oxysterol biochemistry: New discoveries in lipidomics |
title | An update on oxysterol biochemistry: New discoveries in lipidomics |
title_full | An update on oxysterol biochemistry: New discoveries in lipidomics |
title_fullStr | An update on oxysterol biochemistry: New discoveries in lipidomics |
title_full_unstemmed | An update on oxysterol biochemistry: New discoveries in lipidomics |
title_short | An update on oxysterol biochemistry: New discoveries in lipidomics |
title_sort | update on oxysterol biochemistry: new discoveries in lipidomics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381446/ https://www.ncbi.nlm.nih.gov/pubmed/29421651 http://dx.doi.org/10.1016/j.bbrc.2018.02.019 |
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