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No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis

OBJECTIVE: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C. pneumonia...

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Autores principales: Edvinsson, Marie, Welvaart, Nicole, Ryttberg, Lars, Wretenberg, Per, Vikerfors, Tomas, Nyström-Rosander, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381461/
https://www.ncbi.nlm.nih.gov/pubmed/30392431
http://dx.doi.org/10.1177/0300060518807062
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author Edvinsson, Marie
Welvaart, Nicole
Ryttberg, Lars
Wretenberg, Per
Vikerfors, Tomas
Nyström-Rosander, Christina
author_facet Edvinsson, Marie
Welvaart, Nicole
Ryttberg, Lars
Wretenberg, Per
Vikerfors, Tomas
Nyström-Rosander, Christina
author_sort Edvinsson, Marie
collection PubMed
description OBJECTIVE: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C. pneumoniae have been demonstrated in patients with reactive arthritis. Both of these microorganisms can cause chronic and persistent infections, with C. trachomatis being the most common cause of reactive arthritis. This study was performed to investigate the presence of C. pneumoniae in a large number of patients with primary OA. METHODS: The study included 75 patients who underwent total knee arthroplasty. During surgery, a synovial biopsy was performed and synovial fluid drawn. Real-time polymerase chain reaction (PCR) of C. pneumoniae was run on all patients, and real-time PCR of bacterial 16S rDNA was conducted on 30 of the 75 patients to screen for the presence of other bacteria. RESULTS: Real-time PCR showed no evidence of the presence of C. pneumoniae in the patients’ specimens, nor were other bacteria detected. CONCLUSIONS: Although an inflammatory component is part of the pathogenesis of OA, we found no evidence indicating that C. pneumoniae is a stimulator of that inflammation.
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spelling pubmed-63814612019-02-27 No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis Edvinsson, Marie Welvaart, Nicole Ryttberg, Lars Wretenberg, Per Vikerfors, Tomas Nyström-Rosander, Christina J Int Med Res Clinical Research Reports OBJECTIVE: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C. pneumoniae have been demonstrated in patients with reactive arthritis. Both of these microorganisms can cause chronic and persistent infections, with C. trachomatis being the most common cause of reactive arthritis. This study was performed to investigate the presence of C. pneumoniae in a large number of patients with primary OA. METHODS: The study included 75 patients who underwent total knee arthroplasty. During surgery, a synovial biopsy was performed and synovial fluid drawn. Real-time polymerase chain reaction (PCR) of C. pneumoniae was run on all patients, and real-time PCR of bacterial 16S rDNA was conducted on 30 of the 75 patients to screen for the presence of other bacteria. RESULTS: Real-time PCR showed no evidence of the presence of C. pneumoniae in the patients’ specimens, nor were other bacteria detected. CONCLUSIONS: Although an inflammatory component is part of the pathogenesis of OA, we found no evidence indicating that C. pneumoniae is a stimulator of that inflammation. SAGE Publications 2018-11-05 2019-02 /pmc/articles/PMC6381461/ /pubmed/30392431 http://dx.doi.org/10.1177/0300060518807062 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Edvinsson, Marie
Welvaart, Nicole
Ryttberg, Lars
Wretenberg, Per
Vikerfors, Tomas
Nyström-Rosander, Christina
No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title_full No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title_fullStr No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title_full_unstemmed No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title_short No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis
title_sort no evidence of chlamydia pneumoniae in the synovia of patients with osteoarthritis
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381461/
https://www.ncbi.nlm.nih.gov/pubmed/30392431
http://dx.doi.org/10.1177/0300060518807062
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