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Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review

Esophageal cancer is the eighth most common form of cancer worldwide, and esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer that arises from epithelial cells of the esophagus. Local lymph node metastasis (LNM) is a typical sign of failure for ESCC clinical treatments, an...

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Autores principales: Li, Juan, Qi, Zhan, Hu, Yuan-Ping, Wang, Yu-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381495/
https://www.ncbi.nlm.nih.gov/pubmed/30616477
http://dx.doi.org/10.1177/0300060518819606
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author Li, Juan
Qi, Zhan
Hu, Yuan-Ping
Wang, Yu-Xiang
author_facet Li, Juan
Qi, Zhan
Hu, Yuan-Ping
Wang, Yu-Xiang
author_sort Li, Juan
collection PubMed
description Esophageal cancer is the eighth most common form of cancer worldwide, and esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer that arises from epithelial cells of the esophagus. Local lymph node metastasis (LNM) is a typical sign of failure for ESCC clinical treatments, and a link has been established between LNM and the aberrant expression of specific biomarkers. In this review, we summarize what is known about nine factors significantly associated with LNM in ESCC patients: phosphatase and tensin homolog (PTEN), mucin 1, vascular endothelial growth factor-C, tumor necrosis factor alpha-induced protein 8 (TNFAIP8), Raf-1 kinase inhibitory protein, stathmin (STMN1), metastasis-associated protein 1, caveolin-1, and interferon-induced transmembrane protein 3. The function of these nine proteins involves four major mechanisms: tumor cell proliferation, tumor cell migration and invasion, epithelium–mesenchymal transition, and chemosensitivity. The roles of PTEN, STMN1, and TNFAIP8 involve at least two of these mechanisms, and we suggest that they are possible biomarkers for predicting LNM in ESCC. However, further retrospective research into PTEN, STMN1, and TNFAIP8 is needed to test their possibilities as indicators.
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spelling pubmed-63814952019-02-27 Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review Li, Juan Qi, Zhan Hu, Yuan-Ping Wang, Yu-Xiang J Int Med Res Reviews Esophageal cancer is the eighth most common form of cancer worldwide, and esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer that arises from epithelial cells of the esophagus. Local lymph node metastasis (LNM) is a typical sign of failure for ESCC clinical treatments, and a link has been established between LNM and the aberrant expression of specific biomarkers. In this review, we summarize what is known about nine factors significantly associated with LNM in ESCC patients: phosphatase and tensin homolog (PTEN), mucin 1, vascular endothelial growth factor-C, tumor necrosis factor alpha-induced protein 8 (TNFAIP8), Raf-1 kinase inhibitory protein, stathmin (STMN1), metastasis-associated protein 1, caveolin-1, and interferon-induced transmembrane protein 3. The function of these nine proteins involves four major mechanisms: tumor cell proliferation, tumor cell migration and invasion, epithelium–mesenchymal transition, and chemosensitivity. The roles of PTEN, STMN1, and TNFAIP8 involve at least two of these mechanisms, and we suggest that they are possible biomarkers for predicting LNM in ESCC. However, further retrospective research into PTEN, STMN1, and TNFAIP8 is needed to test their possibilities as indicators. SAGE Publications 2019-01-07 2019-02 /pmc/articles/PMC6381495/ /pubmed/30616477 http://dx.doi.org/10.1177/0300060518819606 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Li, Juan
Qi, Zhan
Hu, Yuan-Ping
Wang, Yu-Xiang
Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title_full Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title_fullStr Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title_full_unstemmed Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title_short Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
title_sort possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381495/
https://www.ncbi.nlm.nih.gov/pubmed/30616477
http://dx.doi.org/10.1177/0300060518819606
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