Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia

Primary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall...

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Autores principales: Lin, Yan, Lin, Rongrong, Zhou, Guangquan, Liu, Yue, Dong, Weimin, Cao, Yang, Xie, Xiaobao, Gu, Weiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381513/
https://www.ncbi.nlm.nih.gov/pubmed/30616420
http://dx.doi.org/10.1177/0300060518820147
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author Lin, Yan
Lin, Rongrong
Zhou, Guangquan
Liu, Yue
Dong, Weimin
Cao, Yang
Xie, Xiaobao
Gu, Weiying
author_facet Lin, Yan
Lin, Rongrong
Zhou, Guangquan
Liu, Yue
Dong, Weimin
Cao, Yang
Xie, Xiaobao
Gu, Weiying
author_sort Lin, Yan
collection PubMed
description Primary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall survival of only 2.6 months in patients receiving supportive treatment. To date, treatment of AML transformation remains poor. The case of a 58-year-old female patient with AML transformed from PMF, who was treated with decitabine combined with all-trans retinoic acid, is reported. The patient had complete remission and a 17-month overall survival from initial diagnosis of transformed AML, with tolerated haematologic toxicity during the treatment period.
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spelling pubmed-63815132019-02-27 Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia Lin, Yan Lin, Rongrong Zhou, Guangquan Liu, Yue Dong, Weimin Cao, Yang Xie, Xiaobao Gu, Weiying J Int Med Res Case Reports Primary myelofibrosis (PMF) is a type of cloned myeloproliferative neoplasm stemming from haematopoietic stem cells, and tends to transform to acute myeloid leukaemia (AML) in approximately 10–20% of cases over a 10-year period. The transformation into AML has a poor prognosis, with a median overall survival of only 2.6 months in patients receiving supportive treatment. To date, treatment of AML transformation remains poor. The case of a 58-year-old female patient with AML transformed from PMF, who was treated with decitabine combined with all-trans retinoic acid, is reported. The patient had complete remission and a 17-month overall survival from initial diagnosis of transformed AML, with tolerated haematologic toxicity during the treatment period. SAGE Publications 2019-01-07 2019-02 /pmc/articles/PMC6381513/ /pubmed/30616420 http://dx.doi.org/10.1177/0300060518820147 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Lin, Yan
Lin, Rongrong
Zhou, Guangquan
Liu, Yue
Dong, Weimin
Cao, Yang
Xie, Xiaobao
Gu, Weiying
Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title_full Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title_fullStr Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title_full_unstemmed Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title_short Decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
title_sort decitabine combined with all-trans retinoic acid as treatment in a case of primary myelofibrosis transforming into acute myeloid leukaemia
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381513/
https://www.ncbi.nlm.nih.gov/pubmed/30616420
http://dx.doi.org/10.1177/0300060518820147
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