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Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energet...

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Detalles Bibliográficos
Autores principales: Papa, Luena, Djedaini, Mansour, Hoffman, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381553/
https://www.ncbi.nlm.nih.gov/pubmed/30881461
http://dx.doi.org/10.1155/2019/4067162
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author Papa, Luena
Djedaini, Mansour
Hoffman, Ronald
author_facet Papa, Luena
Djedaini, Mansour
Hoffman, Ronald
author_sort Papa, Luena
collection PubMed
description Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energetic demands of HSCs. Metabolic rewiring from glycolysis to mitochondrial-based energy generation accompanies HSC differentiation and lineage commitment. Recent evidence, however, highlights that alterations in mitochondrial metabolism and activity are not simply passive consequences but active drivers of HSC fate decisions. Modulation of mitochondrial activity and metabolism is therefore critical for maintaining the self-renewal potential of primitive HSCs and might be beneficial for ex vivo expansion of transplantable HSCs. In this review, we emphasize recent advances in the emerging role of mitochondria in hematopoiesis, cellular reprograming, and HSC fate decisions.
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spelling pubmed-63815532019-03-17 Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells Papa, Luena Djedaini, Mansour Hoffman, Ronald Stem Cells Int Review Article Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energetic demands of HSCs. Metabolic rewiring from glycolysis to mitochondrial-based energy generation accompanies HSC differentiation and lineage commitment. Recent evidence, however, highlights that alterations in mitochondrial metabolism and activity are not simply passive consequences but active drivers of HSC fate decisions. Modulation of mitochondrial activity and metabolism is therefore critical for maintaining the self-renewal potential of primitive HSCs and might be beneficial for ex vivo expansion of transplantable HSCs. In this review, we emphasize recent advances in the emerging role of mitochondria in hematopoiesis, cellular reprograming, and HSC fate decisions. Hindawi 2019-02-06 /pmc/articles/PMC6381553/ /pubmed/30881461 http://dx.doi.org/10.1155/2019/4067162 Text en Copyright © 2019 Luena Papa et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Papa, Luena
Djedaini, Mansour
Hoffman, Ronald
Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title_full Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title_fullStr Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title_full_unstemmed Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title_short Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells
title_sort mitochondrial role in stemness and differentiation of hematopoietic stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381553/
https://www.ncbi.nlm.nih.gov/pubmed/30881461
http://dx.doi.org/10.1155/2019/4067162
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