Cargando…
What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study
BACKGROUND: The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its component...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381695/ https://www.ncbi.nlm.nih.gov/pubmed/30782138 http://dx.doi.org/10.1186/s12876-019-0950-z |
_version_ | 1783396552701640704 |
---|---|
author | Hsieh, Yi-Hsuan Wu, Mei-Fong Yang, Pei-Yu Liao, Wei-Cheng Hsieh, Yao-Hsuan Chang, Yu-Jun Lin, I-Ching |
author_facet | Hsieh, Yi-Hsuan Wu, Mei-Fong Yang, Pei-Yu Liao, Wei-Cheng Hsieh, Yao-Hsuan Chang, Yu-Jun Lin, I-Ching |
author_sort | Hsieh, Yi-Hsuan |
collection | PubMed |
description | BACKGROUND: The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its components. METHODS: We conducted a cross-sectional study during 2013 to 2014 in Taiwan. A total of 4895 subjects who completed upper gastrointestinal endoscopy at the Health Examination Center of Changhua Christian Hospital were enrolled. RE was defined according to the upper gastrointestinal endoscopic findings and MetS was defined according to the Taiwanese criteria. Univariate and multivariate logistic regression analyses were applied to calculate odds ratios and 95% confidence intervals for each variable to assess the associated features for RE. We analyzed the relationship between the number of MetS components and the severity of RE using the chi-square test for trend. RESULTS: The prevalence rates of MetS and RE were respectively 28.5 and 59.6%. According to univariate logistic regression analysis, MetS was significantly associated with RE and remained a positive association in multivariate logistic regression analysis (adjusted OR(ß) = 1.251; 95% CI = 1.071–1.462; p = 0.005). Furthermore, among the five MetS components, elevated blood pressure (adjusted OR(γ) = 1.163; 95% CI = 1.023–1.323; p = 0.021), abdominal obesity (adjusted OR(γ) = 1.173; 95% CI = 1.020–1.349; p = 0.026) and hyperglycemia (adjusted OR(γ) = 1.306; 95% CI = 1.142–1.495; p < 0.001) were positively associated with the presence of RE. A weak association was also found between elevated triglycerides and RE after adjusting for age and gender (adjusted OR(α) = 1.171; 95% CI = 1.022–1.343; p = 0.023). Reduced high-density lipoprotein cholesterol showed no significant difference between groups with and without RE. Older age (≥65 years), male gender, higher body mass index, higher uric acid, smoking, alcohol drinking, and hiatal hernia were found to be significant associated factors for RE. In addition, a dose-response relation between the number of MetS components and the presence of RE was demonstrated in the multivariate analysis. Furthermore, we performed a trend analysis and found the severity of RE got worse as the number of MetS components increased (p < 0.001). CONCLUSION: This study suggests that MetS is significantly related to the presence and the severity of RE. |
format | Online Article Text |
id | pubmed-6381695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63816952019-03-01 What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study Hsieh, Yi-Hsuan Wu, Mei-Fong Yang, Pei-Yu Liao, Wei-Cheng Hsieh, Yao-Hsuan Chang, Yu-Jun Lin, I-Ching BMC Gastroenterol Research Article BACKGROUND: The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its components. METHODS: We conducted a cross-sectional study during 2013 to 2014 in Taiwan. A total of 4895 subjects who completed upper gastrointestinal endoscopy at the Health Examination Center of Changhua Christian Hospital were enrolled. RE was defined according to the upper gastrointestinal endoscopic findings and MetS was defined according to the Taiwanese criteria. Univariate and multivariate logistic regression analyses were applied to calculate odds ratios and 95% confidence intervals for each variable to assess the associated features for RE. We analyzed the relationship between the number of MetS components and the severity of RE using the chi-square test for trend. RESULTS: The prevalence rates of MetS and RE were respectively 28.5 and 59.6%. According to univariate logistic regression analysis, MetS was significantly associated with RE and remained a positive association in multivariate logistic regression analysis (adjusted OR(ß) = 1.251; 95% CI = 1.071–1.462; p = 0.005). Furthermore, among the five MetS components, elevated blood pressure (adjusted OR(γ) = 1.163; 95% CI = 1.023–1.323; p = 0.021), abdominal obesity (adjusted OR(γ) = 1.173; 95% CI = 1.020–1.349; p = 0.026) and hyperglycemia (adjusted OR(γ) = 1.306; 95% CI = 1.142–1.495; p < 0.001) were positively associated with the presence of RE. A weak association was also found between elevated triglycerides and RE after adjusting for age and gender (adjusted OR(α) = 1.171; 95% CI = 1.022–1.343; p = 0.023). Reduced high-density lipoprotein cholesterol showed no significant difference between groups with and without RE. Older age (≥65 years), male gender, higher body mass index, higher uric acid, smoking, alcohol drinking, and hiatal hernia were found to be significant associated factors for RE. In addition, a dose-response relation between the number of MetS components and the presence of RE was demonstrated in the multivariate analysis. Furthermore, we performed a trend analysis and found the severity of RE got worse as the number of MetS components increased (p < 0.001). CONCLUSION: This study suggests that MetS is significantly related to the presence and the severity of RE. BioMed Central 2019-02-19 /pmc/articles/PMC6381695/ /pubmed/30782138 http://dx.doi.org/10.1186/s12876-019-0950-z Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Hsieh, Yi-Hsuan Wu, Mei-Fong Yang, Pei-Yu Liao, Wei-Cheng Hsieh, Yao-Hsuan Chang, Yu-Jun Lin, I-Ching What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title | What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title_full | What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title_fullStr | What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title_full_unstemmed | What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title_short | What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study |
title_sort | what is the impact of metabolic syndrome and its components on reflux esophagitis? a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381695/ https://www.ncbi.nlm.nih.gov/pubmed/30782138 http://dx.doi.org/10.1186/s12876-019-0950-z |
work_keys_str_mv | AT hsiehyihsuan whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT wumeifong whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT yangpeiyu whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT liaoweicheng whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT hsiehyaohsuan whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT changyujun whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy AT liniching whatistheimpactofmetabolicsyndromeanditscomponentsonrefluxesophagitisacrosssectionalstudy |