Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells

BACKGROUND: Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is associated with a pronounced increase in mitochondrial respiration. Glucose stimul...

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Detalles Bibliográficos
Autores principales: Santo-Domingo, Jaime, Galindo, Antonio Núñez, Cominetti, Ornella, De Marchi, Umberto, Cutillas, Pedro, Dayon, Loïc, Wiederkehr, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381748/
https://www.ncbi.nlm.nih.gov/pubmed/30786936
http://dx.doi.org/10.1186/s12964-019-0326-6

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