Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene ex...

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Detalles Bibliográficos
Autores principales: Vigilante, Alessandra, Laddach, Anna, Moens, Nathalie, Meleckyte, Ruta, Leha, Andreas, Ghahramani, Arsham, Culley, Oliver J., Kathuria, Annie, Hurling, Chloe, Vickers, Alice, Wiseman, Erika, Tewary, Mukul, Zandstra, Peter W., Durbin, Richard, Fraternali, Franca, Stegle, Oliver, Birney, Ewan, Luscombe, Nicholas M., Danovi, Davide, Watt, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381787/
https://www.ncbi.nlm.nih.gov/pubmed/30784590
http://dx.doi.org/10.1016/j.celrep.2019.01.094

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