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Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895/ https://www.ncbi.nlm.nih.gov/pubmed/30792637 http://dx.doi.org/10.1159/000496052 |
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author | Verga, Emanuele Chohan, Brinder Verdolini, Roberto |
author_facet | Verga, Emanuele Chohan, Brinder Verdolini, Roberto |
author_sort | Verga, Emanuele |
collection | PubMed |
description | Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old female with a large, invasive, malignant melanoma of the malleolar area. Due to the size of the lesion, its location, and the patient's general condition, neither surgery nor radiotherapy were indicated. We offered topical treatment with 5% imiquimod to be applied once/day continuously over a 3-month period, pausing only when intense inflammation on the area of application occurred. Complete clinical and histological resolution of the lesion were observed. This case adds further merit to the growing body of evidence that imiquimod can be used to successfully treat malignant melanoma in cases where no other options are suitable. |
format | Online Article Text |
id | pubmed-6381895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-63818952019-02-21 Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation Verga, Emanuele Chohan, Brinder Verdolini, Roberto Case Rep Dermatol Single Case Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old female with a large, invasive, malignant melanoma of the malleolar area. Due to the size of the lesion, its location, and the patient's general condition, neither surgery nor radiotherapy were indicated. We offered topical treatment with 5% imiquimod to be applied once/day continuously over a 3-month period, pausing only when intense inflammation on the area of application occurred. Complete clinical and histological resolution of the lesion were observed. This case adds further merit to the growing body of evidence that imiquimod can be used to successfully treat malignant melanoma in cases where no other options are suitable. S. Karger AG 2019-01-10 /pmc/articles/PMC6381895/ /pubmed/30792637 http://dx.doi.org/10.1159/000496052 Text en Copyright © 2019 by S. Karger AG, Basel |
spellingShingle | Single Case Verga, Emanuele Chohan, Brinder Verdolini, Roberto Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title | Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title_full | Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title_fullStr | Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title_full_unstemmed | Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title_short | Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation |
title_sort | malignant melanoma treated with topical imiquimod: a bespoke treatment that spared the amputation |
topic | Single Case |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895/ https://www.ncbi.nlm.nih.gov/pubmed/30792637 http://dx.doi.org/10.1159/000496052 |
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