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Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation

Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old...

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Autores principales: Verga, Emanuele, Chohan, Brinder, Verdolini, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895/
https://www.ncbi.nlm.nih.gov/pubmed/30792637
http://dx.doi.org/10.1159/000496052
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author Verga, Emanuele
Chohan, Brinder
Verdolini, Roberto
author_facet Verga, Emanuele
Chohan, Brinder
Verdolini, Roberto
author_sort Verga, Emanuele
collection PubMed
description Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old female with a large, invasive, malignant melanoma of the malleolar area. Due to the size of the lesion, its location, and the patient's general condition, neither surgery nor radiotherapy were indicated. We offered topical treatment with 5% imiquimod to be applied once/day continuously over a 3-month period, pausing only when intense inflammation on the area of application occurred. Complete clinical and histological resolution of the lesion were observed. This case adds further merit to the growing body of evidence that imiquimod can be used to successfully treat malignant melanoma in cases where no other options are suitable.
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spelling pubmed-63818952019-02-21 Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation Verga, Emanuele Chohan, Brinder Verdolini, Roberto Case Rep Dermatol Single Case Surgical excision represents the primary treatment for malignant melanoma. On occasion, however, surgery may not be possible, and a different approach is required. Imiquimod is a Toll-like receptor 7 agonist involved in the activation of the innate immune system. We report the case of a 77-year-old female with a large, invasive, malignant melanoma of the malleolar area. Due to the size of the lesion, its location, and the patient's general condition, neither surgery nor radiotherapy were indicated. We offered topical treatment with 5% imiquimod to be applied once/day continuously over a 3-month period, pausing only when intense inflammation on the area of application occurred. Complete clinical and histological resolution of the lesion were observed. This case adds further merit to the growing body of evidence that imiquimod can be used to successfully treat malignant melanoma in cases where no other options are suitable. S. Karger AG 2019-01-10 /pmc/articles/PMC6381895/ /pubmed/30792637 http://dx.doi.org/10.1159/000496052 Text en Copyright © 2019 by S. Karger AG, Basel
spellingShingle Single Case
Verga, Emanuele
Chohan, Brinder
Verdolini, Roberto
Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title_full Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title_fullStr Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title_full_unstemmed Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title_short Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
title_sort malignant melanoma treated with topical imiquimod: a bespoke treatment that spared the amputation
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381895/
https://www.ncbi.nlm.nih.gov/pubmed/30792637
http://dx.doi.org/10.1159/000496052
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