Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma

Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. To the best of our k...

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Autores principales: Rouvinov, Keren, Nalbandyan, Karen, Kozlov, Victor, Peled, Nir, Yakobson, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381922/
https://www.ncbi.nlm.nih.gov/pubmed/30792642
http://dx.doi.org/10.1159/000495980
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author Rouvinov, Keren
Nalbandyan, Karen
Kozlov, Victor
Peled, Nir
Yakobson, Alexander
author_facet Rouvinov, Keren
Nalbandyan, Karen
Kozlov, Victor
Peled, Nir
Yakobson, Alexander
author_sort Rouvinov, Keren
collection PubMed
description Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. To the best of our knowledge, there are only three published case reports that have shown aplastic anemia in patients who have been treated by immunotherapy. This is the first report of a lethal aplastic anemia during nivolumab monotherapy in a metastatic melanoma patient.
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spelling pubmed-63819222019-02-21 Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma Rouvinov, Keren Nalbandyan, Karen Kozlov, Victor Peled, Nir Yakobson, Alexander Case Rep Oncol Case Report Nivolumab is an active treatment in patients with metastatic melanoma. We report a case of a patient with metastatic malignant melanoma who was given nivolumab as an advanced-line treatment. She received nivolumab 3 mg/kg every 2 weeks for 4 cycles and developed aplastic anemia. To the best of our knowledge, there are only three published case reports that have shown aplastic anemia in patients who have been treated by immunotherapy. This is the first report of a lethal aplastic anemia during nivolumab monotherapy in a metastatic melanoma patient. S. Karger AG 2019-01-04 /pmc/articles/PMC6381922/ /pubmed/30792642 http://dx.doi.org/10.1159/000495980 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Rouvinov, Keren
Nalbandyan, Karen
Kozlov, Victor
Peled, Nir
Yakobson, Alexander
Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title_full Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title_fullStr Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title_full_unstemmed Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title_short Nivolumab Induced Lethal Aplastic Anemia in a Patient with Metastatic Melanoma
title_sort nivolumab induced lethal aplastic anemia in a patient with metastatic melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381922/
https://www.ncbi.nlm.nih.gov/pubmed/30792642
http://dx.doi.org/10.1159/000495980
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AT pelednir nivolumabinducedlethalaplasticanemiainapatientwithmetastaticmelanoma
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