Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model

As Alzheimer’s disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ(42) peptide and inhibited the inflammatory response in primary cellular...

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Autores principales: Caillaud, Martial, Guillard, Jérôme, Richard, Damien, Milin, Serge, Chassaing, Damien, Paccalin, Marc, Page, Guylène, Rioux Bilan, Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382128/
https://www.ncbi.nlm.nih.gov/pubmed/30785960
http://dx.doi.org/10.1371/journal.pone.0212663
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author Caillaud, Martial
Guillard, Jérôme
Richard, Damien
Milin, Serge
Chassaing, Damien
Paccalin, Marc
Page, Guylène
Rioux Bilan, Agnès
author_facet Caillaud, Martial
Guillard, Jérôme
Richard, Damien
Milin, Serge
Chassaing, Damien
Paccalin, Marc
Page, Guylène
Rioux Bilan, Agnès
author_sort Caillaud, Martial
collection PubMed
description As Alzheimer’s disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ(42) peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
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spelling pubmed-63821282019-03-01 Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model Caillaud, Martial Guillard, Jérôme Richard, Damien Milin, Serge Chassaing, Damien Paccalin, Marc Page, Guylène Rioux Bilan, Agnès PLoS One Research Article As Alzheimer’s disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ(42) peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age. Public Library of Science 2019-02-20 /pmc/articles/PMC6382128/ /pubmed/30785960 http://dx.doi.org/10.1371/journal.pone.0212663 Text en © 2019 Caillaud et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Caillaud, Martial
Guillard, Jérôme
Richard, Damien
Milin, Serge
Chassaing, Damien
Paccalin, Marc
Page, Guylène
Rioux Bilan, Agnès
Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title_full Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title_fullStr Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title_full_unstemmed Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title_short Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model
title_sort trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic alzheimer model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382128/
https://www.ncbi.nlm.nih.gov/pubmed/30785960
http://dx.doi.org/10.1371/journal.pone.0212663
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