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The risk factors for diabetic peripheral neuropathy: A meta-analysis

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious cons...

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Detalles Bibliográficos
Autores principales: Liu, Xiuxiu, Xu, Yuyan, An, Miaomiao, Zeng, Qibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382168/
https://www.ncbi.nlm.nih.gov/pubmed/30785930
http://dx.doi.org/10.1371/journal.pone.0212574
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author Liu, Xiuxiu
Xu, Yuyan
An, Miaomiao
Zeng, Qibing
author_facet Liu, Xiuxiu
Xu, Yuyan
An, Miaomiao
Zeng, Qibing
author_sort Liu, Xiuxiu
collection PubMed
description Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). However, most of the aforementioned studies are cross-sectional, and the sample sizes are very limited, so the strength of causal reasoning is relatively low. The current study systematically evaluated DPN’s influencing factors in patients with type 2 diabetes using evidence-based medicine. Overall, 16 included studies (14 cross-sectional studies and 2 case-control studies including 12,116 cases) that conformed to the present criteria were included in the final analysis. The results suggested that the duration of diabetes (MD 2.5, 95% CI 1.71~3.29), age (MD 4.00, 95% CI 3.05~4.95), HbA1c (MD 0.48, 95% CI 0.33~0.64), and DR (OR 2.34, 95% CI 1.74~3.16) are associated with significantly increased risks of DPN among diabetic patients, while BMI, smoking, total triglyceride (TG), and total cholesterol (TC) did not indicate any risks of increasing DPN. The findings provide a scientific basis for a further understanding of the causes of type 2 diabetes complicated with peripheral neuropathy and the improvement of preventive strategies. The next step is to conduct further high-quality prospective cohort studies to validate this paper’s findings.
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spelling pubmed-63821682019-03-01 The risk factors for diabetic peripheral neuropathy: A meta-analysis Liu, Xiuxiu Xu, Yuyan An, Miaomiao Zeng, Qibing PLoS One Research Article Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). However, most of the aforementioned studies are cross-sectional, and the sample sizes are very limited, so the strength of causal reasoning is relatively low. The current study systematically evaluated DPN’s influencing factors in patients with type 2 diabetes using evidence-based medicine. Overall, 16 included studies (14 cross-sectional studies and 2 case-control studies including 12,116 cases) that conformed to the present criteria were included in the final analysis. The results suggested that the duration of diabetes (MD 2.5, 95% CI 1.71~3.29), age (MD 4.00, 95% CI 3.05~4.95), HbA1c (MD 0.48, 95% CI 0.33~0.64), and DR (OR 2.34, 95% CI 1.74~3.16) are associated with significantly increased risks of DPN among diabetic patients, while BMI, smoking, total triglyceride (TG), and total cholesterol (TC) did not indicate any risks of increasing DPN. The findings provide a scientific basis for a further understanding of the causes of type 2 diabetes complicated with peripheral neuropathy and the improvement of preventive strategies. The next step is to conduct further high-quality prospective cohort studies to validate this paper’s findings. Public Library of Science 2019-02-20 /pmc/articles/PMC6382168/ /pubmed/30785930 http://dx.doi.org/10.1371/journal.pone.0212574 Text en © 2019 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Liu, Xiuxiu
Xu, Yuyan
An, Miaomiao
Zeng, Qibing
The risk factors for diabetic peripheral neuropathy: A meta-analysis
title The risk factors for diabetic peripheral neuropathy: A meta-analysis
title_full The risk factors for diabetic peripheral neuropathy: A meta-analysis
title_fullStr The risk factors for diabetic peripheral neuropathy: A meta-analysis
title_full_unstemmed The risk factors for diabetic peripheral neuropathy: A meta-analysis
title_short The risk factors for diabetic peripheral neuropathy: A meta-analysis
title_sort risk factors for diabetic peripheral neuropathy: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382168/
https://www.ncbi.nlm.nih.gov/pubmed/30785930
http://dx.doi.org/10.1371/journal.pone.0212574
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