PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (...

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Detalles Bibliográficos
Autores principales: Buckley, Catherine M., Heath, Victoria L., Guého, Aurélie, Bosmani, Cristina, Knobloch, Paulina, Sikakana, Phumzile, Personnic, Nicolas, Dove, Stephen K., Michell, Robert H., Meier, Roger, Hilbi, Hubert, Soldati, Thierry, Insall, Robert H., King, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382210/
https://www.ncbi.nlm.nih.gov/pubmed/30730983
http://dx.doi.org/10.1371/journal.ppat.1007551

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