Biohybrid Circuits: Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A (Adv. Sci. 4/2019)

In article number 1801320, Wilfried Weber and co‐workers present the incorporation of biological circuits into polymer materials capable of sensing and processing an input stimulus and producing a quantitative output. Positive feedback and/or feedforward network topologies detect the proteolytic act...

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Detalles Bibliográficos
Autores principales: Wagner, Hanna J., Kemmer, Svenja, Engesser, Raphael, Timmer, Jens, Weber, Wilfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382299/
http://dx.doi.org/10.1002/advs.201970020
Descripción
Sumario:In article number 1801320, Wilfried Weber and co‐workers present the incorporation of biological circuits into polymer materials capable of sensing and processing an input stimulus and producing a quantitative output. Positive feedback and/or feedforward network topologies detect the proteolytic activity of botulinum toxin A with adjustable kinetics and dynamic range. Image credit: Jo Richers (www.jorichers.com). [Image: see text]

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