Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co‐workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an...

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Detalles Bibliográficos
Autores principales: Lu, Yifei, Guo, Zhongyuan, Zhang, Yujie, Li, Chao, Zhang, Yu, Guo, Qin, Chen, Qinjun, Chen, Xinli, He, Xi, Liu, Lisha, Ruan, Chunhui, Sun, Tao, Ji, Bin, Lu, Weigen, Jiang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382302/
http://dx.doi.org/10.1002/advs.201970024
Descripción
Sumario:An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co‐workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an early phase of AD. Through its efficient neuroprotection and microglia modulatory functions, decreased Aβ plaque burdens and improved cognition are achieved. [Image: see text]

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