Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

Nonhepatic delivery of small interfering RNAs (siRNAs) remains a challenge for development of RNA interference–based therapeutics. We report a noncationic vector wherein linear poly(ethylene glycol) (PEG), a polymer generally considered as inert and safe biologically but ineffective as a vector, is...

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Detalles Bibliográficos
Autores principales: Wang, Dali, Lin, Jiaqi, Jia, Fei, Tan, Xuyu, Wang, Yuyan, Sun, Xiaoya, Cao, Xueyan, Che, Fangyuan, Lu, Hao, Gao, Ximing, Shimkonis, Jackson Christopher, Nyoni, Zifiso, Lu, Xueguang, Zhang, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382396/
https://www.ncbi.nlm.nih.gov/pubmed/30801019
http://dx.doi.org/10.1126/sciadv.aav9322

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