Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

Production of interleukin-17 (IL-17) and IL-22 by T helper 17 (Th17) cells and group 3 innate lymphoid cells (ILC3s) in response to the gut microbiota ensures maintenance of intestinal barrier function. Here, we examined the mechanisms whereby the immune system detects microbiota in the steady state...

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Detalles Bibliográficos
Autores principales: Martínez-López, María, Iborra, Salvador, Conde-Garrosa, Ruth, Mastrangelo, Annalaura, Danne, Camille, Mann, Elizabeth R., Reid, Delyth M., Gaboriau-Routhiau, Valérie, Chaparro, Maria, Lorenzo, María P., Minnerup, Lara, Saz-Leal, Paula, Slack, Emma, Kemp, Benjamin, Gisbert, Javier P., Dzionek, Andrzej, Robinson, Matthew J., Rupérez, Francisco J., Cerf-Bensussan, Nadine, Brown, Gordon D., Bernardo, David, LeibundGut-Landmann, Salomé, Sancho, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382412/
https://www.ncbi.nlm.nih.gov/pubmed/30709742
http://dx.doi.org/10.1016/j.immuni.2018.12.020

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