Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4(+) regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and spleen....

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Detalles Bibliográficos
Autores principales: Miragaia, Ricardo J., Gomes, Tomás, Chomka, Agnieszka, Jardine, Laura, Riedel, Angela, Hegazy, Ahmed N., Whibley, Natasha, Tucci, Andrea, Chen, Xi, Lindeman, Ida, Emerton, Guy, Krausgruber, Thomas, Shields, Jacqueline, Haniffa, Muzlifah, Powrie, Fiona, Teichmann, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382439/
https://www.ncbi.nlm.nih.gov/pubmed/30737144
http://dx.doi.org/10.1016/j.immuni.2019.01.001

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