Lack of association of the IL‐1RN and IL‐10 polymorphisms with risk of psoriasis: A meta‐analysis

BACKGROUND: The present study carried out a meta‐analysis to investigate whether the interleukin‐1 receptor antagonist (IL‐1RN) VNTR polymorphism and three IL‐10 single‐nucleotide polymorphisms (SNPs) rs1800896, rs3021097, and rs1800872 are associated with psoriasis risk. METHODS: Wanfang, China National Knowledge Infrastructure, Medline, and PubMed databases were searched for potential studies published until 2 November 2017. Forest plots were generated. RESULTS: Thirteen case–control studies were included in the review. The results of meta‐analyses revealed no association of the IL‐1RN*2 allele with psoriasis in the overall populations (odds ratio [OR] = 1.16, 95% confidence intervals [CI]: 0.89–1.50, p = 0.279), Asians (OR = 1.27, 95% CI: 0.73–2.23, p = 0.403), and Caucasians (OR = 1.04, 95% CI: 0.88–1.23, p = 0.669). Under the allelic model, there was no statistically significant association of psoriasis with the IL‐10 SNPs rs1800896 (G allele vs. A allele: OR = 1.03, 95% CI: 0.90–1.18, p = 0.639), rs3021097 (C allele vs. T allele: OR = 1.17, 95% CI: 0.88–1.56, p = 0.288), and rs1800872 (C allele vs. A allele: OR = 1.01, 95% CI: 0.81–1.25, p = 0.951). No publication bias was found by Egger's test and Begg's funnel plots. CONCLUSION: Current published studies fail to support an association of the IL‐1RN VNTR polymorphism and IL‐10 SNPs rs1800896, rs3021097, and rs1800872 with psoriasis risk.