Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

NF-κB (nuclear factor κB) signaling is considered critical for single positive (SP) thymocyte development because loss of upstream activators of NF-κB, such as the IKK complex, arrests their development. We found that the compound ablation of RelA, cRel, and p50, required for canonical NF-κB transcr...

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Detalles Bibliográficos
Autores principales: Webb, Louise V., Barbarulo, Alessandro, Huysentruyt, Jelle, Vanden Berghe, Tom, Takahashi, Nozomi, Ley, Steven, Vandenabeele, Peter, Seddon, Benedict
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382466/
https://www.ncbi.nlm.nih.gov/pubmed/30737145
http://dx.doi.org/10.1016/j.immuni.2019.01.004

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