PLD3 Rare Variants Identified in Late-Onset Alzheimer’s Disease Affect Amyloid-β Levels in Cellular Model

Next-generation sequencing studies have reported that rare variants in PLD3 were associated with increased risk of late-onset Alzheimer’s disease (LOAD) in European cohorts. The association has been replicated in a Han Chinese cohort, two rare variants p.I163M in exon7 and p.R356H in exon11 of PLD3...

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Detalles Bibliográficos
Autores principales: Tan, Mengshan, Li, Jieqiong, Ma, Fangchen, Zhang, Xing, Zhao, Qingfei, Cao, Xipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382672/
https://www.ncbi.nlm.nih.gov/pubmed/30837833
http://dx.doi.org/10.3389/fnins.2019.00116

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