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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite Plasmodium falciparum in vitro and in vivo. Four lead compounds from the thiourea sub-series and one compound from the urea-based analogs we...

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Detalles Bibliográficos
Autores principales:	El Bissati, Kamal, Redel, Henry, Ting, Li-Min, Lykins, Joseph D., McPhillie, Martin J., Upadhya, Rajendra, Woster, Patrick M., Yarlett, Nigel, Kim, Kami, Weiss, Louis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382690/ https://www.ncbi.nlm.nih.gov/pubmed/30838177 http://dx.doi.org/10.3389/fcimb.2019.00009

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