Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca(2+)-activated Cl(−) channel, TMEM16A, offers a new mechanism to bronchodilate airways and block the multiple...

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Detalles Bibliográficos
Autores principales: Miner, Kent, Labitzke, Katja, Liu, Benxian, Wang, Paul, Henckels, Kathryn, Gaida, Kevin, Elliott, Robin, Chen, Jian Jeffrey, Liu, Longbin, Leith, Anh, Trueblood, Esther, Hensley, Kelly, Xia, Xing-Zhong, Homann, Oliver, Bennett, Brian, Fiorino, Mike, Whoriskey, John, Yu, Gang, Escobar, Sabine, Wong, Min, Born, Teresa L., Budelsky, Alison, Comeau, Mike, Smith, Dirk, Phillips, Jonathan, Johnston, James A., McGivern, Joseph G., Weikl, Kerstin, Powers, David, Kunzelmann, Karl, Mohn, Deanna, Hochheimer, Andreas, Sullivan, John K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382696/
https://www.ncbi.nlm.nih.gov/pubmed/30837866
http://dx.doi.org/10.3389/fphar.2019.00051

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