Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron diseases: amyotrophic lateral sclerosis (ALS) a...

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Detalles Bibliográficos
Autores principales: Prasad, Archana, Bharathi, Vidhya, Sivalingam, Vishwanath, Girdhar, Amandeep, Patel, Basant K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382748/
https://www.ncbi.nlm.nih.gov/pubmed/30837838
http://dx.doi.org/10.3389/fnmol.2019.00025

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