Cargando…

Outcomes of controlled human malaria infection after BCG vaccination

Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy m...

Descripción completa

Detalles Bibliográficos
Autores principales: Walk, Jona, de Bree, L. Charlotte J., Graumans, Wouter, Stoter, Rianne, van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, Teelen, Karina, Hermsen, Cornelus C., Arts, Rob J. W., Behet, Marije C., Keramati, Farid, Moorlag, Simone J. C. F. M., Yang, Annie S. P., van Crevel, Reinout, Aaby, Peter, de Mast, Quirijn, van der Ven, André J. A. M., Stabell Benn, Christine, Netea, Mihai G., Sauerwein, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382772/
https://www.ncbi.nlm.nih.gov/pubmed/30787276
http://dx.doi.org/10.1038/s41467-019-08659-3
_version_ 1783396713890840576
author Walk, Jona
de Bree, L. Charlotte J.
Graumans, Wouter
Stoter, Rianne
van Gemert, Geert-Jan
van de Vegte-Bolmer, Marga
Teelen, Karina
Hermsen, Cornelus C.
Arts, Rob J. W.
Behet, Marije C.
Keramati, Farid
Moorlag, Simone J. C. F. M.
Yang, Annie S. P.
van Crevel, Reinout
Aaby, Peter
de Mast, Quirijn
van der Ven, André J. A. M.
Stabell Benn, Christine
Netea, Mihai G.
Sauerwein, Robert W.
author_facet Walk, Jona
de Bree, L. Charlotte J.
Graumans, Wouter
Stoter, Rianne
van Gemert, Geert-Jan
van de Vegte-Bolmer, Marga
Teelen, Karina
Hermsen, Cornelus C.
Arts, Rob J. W.
Behet, Marije C.
Keramati, Farid
Moorlag, Simone J. C. F. M.
Yang, Annie S. P.
van Crevel, Reinout
Aaby, Peter
de Mast, Quirijn
van der Ven, André J. A. M.
Stabell Benn, Christine
Netea, Mihai G.
Sauerwein, Robert W.
author_sort Walk, Jona
collection PubMed
description Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development.
format Online
Article
Text
id pubmed-6382772
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-63827722019-02-22 Outcomes of controlled human malaria infection after BCG vaccination Walk, Jona de Bree, L. Charlotte J. Graumans, Wouter Stoter, Rianne van Gemert, Geert-Jan van de Vegte-Bolmer, Marga Teelen, Karina Hermsen, Cornelus C. Arts, Rob J. W. Behet, Marije C. Keramati, Farid Moorlag, Simone J. C. F. M. Yang, Annie S. P. van Crevel, Reinout Aaby, Peter de Mast, Quirijn van der Ven, André J. A. M. Stabell Benn, Christine Netea, Mihai G. Sauerwein, Robert W. Nat Commun Article Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382772/ /pubmed/30787276 http://dx.doi.org/10.1038/s41467-019-08659-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Walk, Jona
de Bree, L. Charlotte J.
Graumans, Wouter
Stoter, Rianne
van Gemert, Geert-Jan
van de Vegte-Bolmer, Marga
Teelen, Karina
Hermsen, Cornelus C.
Arts, Rob J. W.
Behet, Marije C.
Keramati, Farid
Moorlag, Simone J. C. F. M.
Yang, Annie S. P.
van Crevel, Reinout
Aaby, Peter
de Mast, Quirijn
van der Ven, André J. A. M.
Stabell Benn, Christine
Netea, Mihai G.
Sauerwein, Robert W.
Outcomes of controlled human malaria infection after BCG vaccination
title Outcomes of controlled human malaria infection after BCG vaccination
title_full Outcomes of controlled human malaria infection after BCG vaccination
title_fullStr Outcomes of controlled human malaria infection after BCG vaccination
title_full_unstemmed Outcomes of controlled human malaria infection after BCG vaccination
title_short Outcomes of controlled human malaria infection after BCG vaccination
title_sort outcomes of controlled human malaria infection after bcg vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382772/
https://www.ncbi.nlm.nih.gov/pubmed/30787276
http://dx.doi.org/10.1038/s41467-019-08659-3
work_keys_str_mv AT walkjona outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT debreelcharlottej outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT graumanswouter outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT stoterrianne outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT vangemertgeertjan outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT vandevegtebolmermarga outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT teelenkarina outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT hermsencornelusc outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT artsrobjw outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT behetmarijec outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT keramatifarid outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT moorlagsimonejcfm outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT yanganniesp outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT vancrevelreinout outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT aabypeter outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT demastquirijn outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT vandervenandrejam outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT stabellbennchristine outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT neteamihaig outcomesofcontrolledhumanmalariainfectionafterbcgvaccination
AT sauerweinrobertw outcomesofcontrolledhumanmalariainfectionafterbcgvaccination