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Outcomes of controlled human malaria infection after BCG vaccination
Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy m...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382772/ https://www.ncbi.nlm.nih.gov/pubmed/30787276 http://dx.doi.org/10.1038/s41467-019-08659-3 |
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author | Walk, Jona de Bree, L. Charlotte J. Graumans, Wouter Stoter, Rianne van Gemert, Geert-Jan van de Vegte-Bolmer, Marga Teelen, Karina Hermsen, Cornelus C. Arts, Rob J. W. Behet, Marije C. Keramati, Farid Moorlag, Simone J. C. F. M. Yang, Annie S. P. van Crevel, Reinout Aaby, Peter de Mast, Quirijn van der Ven, André J. A. M. Stabell Benn, Christine Netea, Mihai G. Sauerwein, Robert W. |
author_facet | Walk, Jona de Bree, L. Charlotte J. Graumans, Wouter Stoter, Rianne van Gemert, Geert-Jan van de Vegte-Bolmer, Marga Teelen, Karina Hermsen, Cornelus C. Arts, Rob J. W. Behet, Marije C. Keramati, Farid Moorlag, Simone J. C. F. M. Yang, Annie S. P. van Crevel, Reinout Aaby, Peter de Mast, Quirijn van der Ven, André J. A. M. Stabell Benn, Christine Netea, Mihai G. Sauerwein, Robert W. |
author_sort | Walk, Jona |
collection | PubMed |
description | Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development. |
format | Online Article Text |
id | pubmed-6382772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63827722019-02-22 Outcomes of controlled human malaria infection after BCG vaccination Walk, Jona de Bree, L. Charlotte J. Graumans, Wouter Stoter, Rianne van Gemert, Geert-Jan van de Vegte-Bolmer, Marga Teelen, Karina Hermsen, Cornelus C. Arts, Rob J. W. Behet, Marije C. Keramati, Farid Moorlag, Simone J. C. F. M. Yang, Annie S. P. van Crevel, Reinout Aaby, Peter de Mast, Quirijn van der Ven, André J. A. M. Stabell Benn, Christine Netea, Mihai G. Sauerwein, Robert W. Nat Commun Article Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG), can induce changes in the innate immune system with non-specific memory characteristics, termed ‘trained immunity’. Here we present the results of a randomised, controlled phase 1 clinical trial in 20 healthy male and female volunteers to evaluate the induction of immunity and protective efficacy of the anti-tuberculosis BCG vaccine against a controlled human malaria infection. After malaria challenge infection, BCG vaccinated volunteers present with earlier and more severe clinical adverse events, and have significantly earlier expression of NK cell activation markers and a trend towards earlier phenotypic monocyte activation. Furthermore, parasitemia in BCG vaccinated volunteers is inversely correlated with increased phenotypic NK cell and monocyte activation. The combined data demonstrate that BCG vaccination alters the clinical and immunological response to malaria, and form an impetus to further explore its potential in strategies for clinical malaria vaccine development. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382772/ /pubmed/30787276 http://dx.doi.org/10.1038/s41467-019-08659-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Walk, Jona de Bree, L. Charlotte J. Graumans, Wouter Stoter, Rianne van Gemert, Geert-Jan van de Vegte-Bolmer, Marga Teelen, Karina Hermsen, Cornelus C. Arts, Rob J. W. Behet, Marije C. Keramati, Farid Moorlag, Simone J. C. F. M. Yang, Annie S. P. van Crevel, Reinout Aaby, Peter de Mast, Quirijn van der Ven, André J. A. M. Stabell Benn, Christine Netea, Mihai G. Sauerwein, Robert W. Outcomes of controlled human malaria infection after BCG vaccination |
title | Outcomes of controlled human malaria infection after BCG vaccination |
title_full | Outcomes of controlled human malaria infection after BCG vaccination |
title_fullStr | Outcomes of controlled human malaria infection after BCG vaccination |
title_full_unstemmed | Outcomes of controlled human malaria infection after BCG vaccination |
title_short | Outcomes of controlled human malaria infection after BCG vaccination |
title_sort | outcomes of controlled human malaria infection after bcg vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382772/ https://www.ncbi.nlm.nih.gov/pubmed/30787276 http://dx.doi.org/10.1038/s41467-019-08659-3 |
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