Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual

Osteoblasts, which are the bone-forming cells, operate in a hypoxic environment. The transcription factors hypoxia-inducible factor-1α (HIF1) and HIF2 are key mediators of the cellular response to hypoxia. Both are expressed in osteoblasts. HIF1 is known to be a positive regulator of bone formation....

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Detalles Bibliográficos
Autores principales: Merceron, Christophe, Ranganathan, Kavitha, Wang, Elizabeth, Tata, Zachary, Makkapati, Shreya, Khan, Mohd Parvez, Mangiavini, Laura, Yao, Angela Qing, Castellini, Laura, Levi, Benjamin, Giaccia, Amato J., Schipani, Ernestina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382776/
https://www.ncbi.nlm.nih.gov/pubmed/30792937
http://dx.doi.org/10.1038/s41413-019-0045-z

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