Cargando…
The AAA+ protease ClpXP can easily degrade a 3(1) and a 5(2)-knotted protein
Knots in proteins are hypothesized to make them resistant to enzymatic degradation by ATP-dependent proteases and recent studies have shown that whereas ClpXP can easily degrade a protein with a shallow 3(1) knot, it cannot degrade 5(2)-knotted proteins if degradation is initiated at the C-terminus....
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382783/ https://www.ncbi.nlm.nih.gov/pubmed/30787316 http://dx.doi.org/10.1038/s41598-018-38173-3 |