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Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection
To fulfill a productive infection cycle the human immunodeficiency virus (HIV) relies on host-cell factors. Interference with these co-factors holds great promise in protecting cells against HIV infection. LEDGF/p75, encoded by the PSIP1 gene, is used by the integrase (IN) protein in the pre-integra...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382798/ https://www.ncbi.nlm.nih.gov/pubmed/30787394 http://dx.doi.org/10.1038/s41598-019-38718-0 |