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A softening laminar electrode for recording single unit activity from the rat hippocampus
Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demon...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382803/ https://www.ncbi.nlm.nih.gov/pubmed/30787389 http://dx.doi.org/10.1038/s41598-019-39835-6 |
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author | Zátonyi, A. Orbán, G. Modi, R. Márton, G. Meszéna, D. Ulbert, I. Pongrácz, A. Ecker, M. Voit, W. E. Joshi-Imre, A. Fekete, Z. |
author_facet | Zátonyi, A. Orbán, G. Modi, R. Márton, G. Meszéna, D. Ulbert, I. Pongrácz, A. Ecker, M. Voit, W. E. Joshi-Imre, A. Fekete, Z. |
author_sort | Zátonyi, A. |
collection | PubMed |
description | Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demonstrate the viability of this material engineering approach. In our paper, we present a robust technology of softening neural microelectrode and demonstrate its recording performance in the hippocampus of rat subjects. The 5 mm long, single shank, multi-channel probes are composed of a custom thiol-ene/acrylate thermoset polymer substrate, and were micromachined by standard MEMS processes. A special packaging technique is also developed, which guarantees the stable functionality and longevity of the device, which were tested under in vitro conditions prior to animal studies. The 60 micron thick device was successfully implanted to 4.5 mm deep in the hippocampus without the aid of any insertion shuttle. Spike amplitudes of 84 µV peak-to-peak and signal-to-noise ratio of 6.24 were achieved in acute experiments. Our study demonstrates that softening neural probes may be used to investigate deep layers of the rat brain. |
format | Online Article Text |
id | pubmed-6382803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63828032019-02-22 A softening laminar electrode for recording single unit activity from the rat hippocampus Zátonyi, A. Orbán, G. Modi, R. Márton, G. Meszéna, D. Ulbert, I. Pongrácz, A. Ecker, M. Voit, W. E. Joshi-Imre, A. Fekete, Z. Sci Rep Article Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demonstrate the viability of this material engineering approach. In our paper, we present a robust technology of softening neural microelectrode and demonstrate its recording performance in the hippocampus of rat subjects. The 5 mm long, single shank, multi-channel probes are composed of a custom thiol-ene/acrylate thermoset polymer substrate, and were micromachined by standard MEMS processes. A special packaging technique is also developed, which guarantees the stable functionality and longevity of the device, which were tested under in vitro conditions prior to animal studies. The 60 micron thick device was successfully implanted to 4.5 mm deep in the hippocampus without the aid of any insertion shuttle. Spike amplitudes of 84 µV peak-to-peak and signal-to-noise ratio of 6.24 were achieved in acute experiments. Our study demonstrates that softening neural probes may be used to investigate deep layers of the rat brain. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382803/ /pubmed/30787389 http://dx.doi.org/10.1038/s41598-019-39835-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zátonyi, A. Orbán, G. Modi, R. Márton, G. Meszéna, D. Ulbert, I. Pongrácz, A. Ecker, M. Voit, W. E. Joshi-Imre, A. Fekete, Z. A softening laminar electrode for recording single unit activity from the rat hippocampus |
title | A softening laminar electrode for recording single unit activity from the rat hippocampus |
title_full | A softening laminar electrode for recording single unit activity from the rat hippocampus |
title_fullStr | A softening laminar electrode for recording single unit activity from the rat hippocampus |
title_full_unstemmed | A softening laminar electrode for recording single unit activity from the rat hippocampus |
title_short | A softening laminar electrode for recording single unit activity from the rat hippocampus |
title_sort | softening laminar electrode for recording single unit activity from the rat hippocampus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382803/ https://www.ncbi.nlm.nih.gov/pubmed/30787389 http://dx.doi.org/10.1038/s41598-019-39835-6 |
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