Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Morphine is a unique opioid analgesic that activates the mu-opioid receptor (MOR) without efficiently promoting its endocytosis that may underlie side effects. Our objective was to discover a novel enhancer of ligand-induced MOR endocytosis and determine its effects on analgesia, tolerance and depen...

Descripción completa

Detalles Bibliográficos
Autores principales: Chao, Po-Kuan, Chang, Hsiao-Fu, Ou, Li-Chin, Chuang, Jian-Ying, Lee, Pin-Tse, Chang, Wan-Ting, Chen, Shu-Chun, Ueng, Shau-Hua, Hsu, John Tsu-An, Tao, Pao-Luh, Law, Ping-Yee, Loh, Horace H., Yeh, Shiu-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382827/
https://www.ncbi.nlm.nih.gov/pubmed/30787373
http://dx.doi.org/10.1038/s41598-019-39555-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382827/
https://www.ncbi.nlm.nih.gov/pubmed/30787373
http://dx.doi.org/10.1038/s41598-019-39555-x

Ejemplares similares