A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4

Histone deacetylases (HDACs) can enzymatically transferred acetyl functional group from protein or lysine residues of histone, so they can regulate the expression of lots of genes. Now HDACs are used as drug targets and many HDAC inhibitors (HDACis) were approved for cancer therapy or in clinical tr...

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Detalles Bibliográficos
Autores principales: Song, Qiuhang, Li, Mingyue, Fan, Cong, Liu, Yucui, Zheng, Lihua, Bao, Yongli, Sun, Luguo, Yu, Chunlei, Song, Zhenbo, Sun, Ying, Wang, Guannan, Huang, Yanxin, Li, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382829/
https://www.ncbi.nlm.nih.gov/pubmed/30787420
http://dx.doi.org/10.1038/s41598-019-39487-6

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