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The indirect health effects of malaria estimated from health advantages of the sickle cell trait
Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait (HbAS),...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382840/ https://www.ncbi.nlm.nih.gov/pubmed/30787300 http://dx.doi.org/10.1038/s41467-019-08775-0 |
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author | Uyoga, Sophie Macharia, Alex W. Ndila, Carolyne M. Nyutu, Gideon Shebe, Mohammed Awuondo, Kennedy O. Mturi, Neema Peshu, Norbert Tsofa, Benjamin Scott, J. Anthony G. Maitland, Kathryn Williams, Thomas N. |
author_facet | Uyoga, Sophie Macharia, Alex W. Ndila, Carolyne M. Nyutu, Gideon Shebe, Mohammed Awuondo, Kennedy O. Mturi, Neema Peshu, Norbert Tsofa, Benjamin Scott, J. Anthony G. Maitland, Kathryn Williams, Thomas N. |
author_sort | Uyoga, Sophie |
collection | PubMed |
description | Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000–2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22–0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67–0.93), bacteraemia (aOR 0.69; 0.54–0.88) and severe malnutrition (aOR 0.67; 0.55–0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions. |
format | Online Article Text |
id | pubmed-6382840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63828402019-02-22 The indirect health effects of malaria estimated from health advantages of the sickle cell trait Uyoga, Sophie Macharia, Alex W. Ndila, Carolyne M. Nyutu, Gideon Shebe, Mohammed Awuondo, Kennedy O. Mturi, Neema Peshu, Norbert Tsofa, Benjamin Scott, J. Anthony G. Maitland, Kathryn Williams, Thomas N. Nat Commun Article Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000–2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22–0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67–0.93), bacteraemia (aOR 0.69; 0.54–0.88) and severe malnutrition (aOR 0.67; 0.55–0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions. Nature Publishing Group UK 2019-02-20 /pmc/articles/PMC6382840/ /pubmed/30787300 http://dx.doi.org/10.1038/s41467-019-08775-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Uyoga, Sophie Macharia, Alex W. Ndila, Carolyne M. Nyutu, Gideon Shebe, Mohammed Awuondo, Kennedy O. Mturi, Neema Peshu, Norbert Tsofa, Benjamin Scott, J. Anthony G. Maitland, Kathryn Williams, Thomas N. The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title_full | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title_fullStr | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title_full_unstemmed | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title_short | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
title_sort | indirect health effects of malaria estimated from health advantages of the sickle cell trait |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382840/ https://www.ncbi.nlm.nih.gov/pubmed/30787300 http://dx.doi.org/10.1038/s41467-019-08775-0 |
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