Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity

The inhibition of the PCSK9/LDLR protein-protein interaction (PPI) is a promising strategy for developing new hypocholesterolemic agents. Recently, new antibodies have been approved for therapy, but the high cost and low patients’ compliance stimulate the development of alternatives. Starting from t...

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Detalles Bibliográficos
Autores principales: Lammi, Carmen, Sgrignani, Jacopo, Arnoldi, Anna, Grazioso, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382862/
https://www.ncbi.nlm.nih.gov/pubmed/30787312
http://dx.doi.org/10.1038/s41598-018-35819-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382862/
https://www.ncbi.nlm.nih.gov/pubmed/30787312
http://dx.doi.org/10.1038/s41598-018-35819-0

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